TY - JOUR
AU - Ory, Steven J.
AB - Abstract Fourteen years ago independent investigations regarding the hypothalamic control of gonadotropin release were simultaneously concluded by two research teams.1,2 These reports presented the isolation and synthesis of a hypothalamic decapeptide now known as gonadotropin-releasing hormone (GnRH) (also known as luteinizing hormone-releasing hormone [LH-RH] or gonadorelin). When given parenterally to humans, this compound results in stimulation of release of the anterior pituitary gonadotropic hormones, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). In 1978 the significance of this accomplishment was recognized by the award of the Nobel Prize for Medicine to the heads of the two research teams. Since its discovery GnRH has been widely used as a reproductive endocrine probe to aid our understanding of basic control mechanisms involved in gonadal function in humans. Additionally, GnRH has been extensively used as a diagnostic tool for men and women with gonadal dysfunction; more recently it has also been utilized as a References 1. Matsuo H, Baba Y, Nair RMG, et al: Structure of the porcine LH and FSH releasing hormone. Biochem Biophys Res Commun 1971;43:1334.Crossref 2. Amoss M, Burgus R, Blackwell R, et al: Purification, amino acid composition and N-terminus of the hypothalamic luteinizing hormone releasing factor of ovine origin. Biochem Biophys Res Commun 1971;44: 205.Crossref 3. Belchetz PE, Plant TM, Nakai Y, et al: Hypophysical responses to continuous and intermittent delivery of hypothalamic GnRH. Science 1978;202:1631.Crossref 4. Yen SSC, Lein A: Reproductive physiology: The human , in Lamming GE (ed): Marshall's Physiology of Reproduction , ed 4. New York, Longmans, Green, in press. 5. Rivier C, Rivier J, Vale W: Chronic effects of [D-Trp6-Pro6-NEt] luteinizing hormone-releasing factor on reproductive processes in the female rat. 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TI - Diagnostic and Therapeutic Uses of Gonadotropin-Releasing Hormone
JO - Archives of Internal Medicine
DO - 10.1001/archinte.1985.00360090166025
DA - 1985-09-01
UR - https://www.deepdyve.com/lp/american-medical-association/diagnostic-and-therapeutic-uses-of-gonadotropin-releasing-hormone-60MJJ8jEy0
SP - 1690
EP - 1697
VL - 145
IS - 9
DP - DeepDyve
ER -