TY - JOUR
AB - Biotechnology Biotechnol. J. 2006, 1, 6 Journal In this issue Using budding yeast to screen for anti-prion drugs Tribouillard et al. Prions are misfolded proteins capable of propagating their altered conformation, commonly considered as the causative agents of some fatal neurodegenerative dis- eases, for which currently no treatment is available. A paper in this issue describes new developments of a novel yeast-based drug screening method, including the use of three different mammalian cell-based assays as secondary screens to unambigu- ously define compounds to be tested in vivo in mouse models for prion-based dis- eases. Confirming previous observations, most of the compounds isolated so far turned out to be also active in promoting mammalian prion clearance. This strongly suggests that biochemical pathways controlling prion formation and/or mainte- nance are conserved from yeast to human and thus amenable to biochemical and genetic analysis, and to pharmacological modulation. In addition, the yeast method could serve as a basis to isolate drugs potentially active against other diseases involving amyloid fibers, like Huntington’s, Parkinson’s or Alzheimer’s disease. ... 58 Electric field driven jetting: an emerging approach for processing living cells Jayasinghe et al. Novel techniques are required for processing suspensions of living cellular materi- 
TI - In this issue: Biotechnology Journal 1/2006
JF - Biotechnology Journal
DO - 10.1002/biot.200690012
DA - 2006-01-01
UR - https://www.deepdyve.com/lp/wiley/in-this-issue-biotechnology-journal-1-2006-5uOVBliE27
SP - 6
EP - 6
VL - 1
IS - 1
DP - DeepDyve
ER -