TY - JOUR AU - Park, Linda AB - Journal of Clinical Immunology, Vol. 10, No. 6, 1990 Special Article STEVEN K. DOWER, 1 CRAIG A. SMITH, 1 and LINDA S. PARK 1 Accepted: September 6, 1990 stimulating factors. The reasons for the assignment of any particular molecule to any particular class of KEY WORDS: Cytokine receptors; tumor necrosis factor; inter- mediators are in large part historical, as it is becom- leukins; immunoglobulin; immune regulation. ing rapidly more evident that all these factors can be viewed as forming one large regulatory network. In INTRODUCTION this review we confine attention to the interleukins Insults such as injury and infection call into play (ILs) 1 through 8, transforming growth factor 13 responses from a wide variety of cells and tissues. (TGF[3), tumor necrosis factor-or (TNFa), tumor These include those immediately affected by, for necrosis factor[3 (TNF13) (also termed lympho- example, a cut or abrasion, for example, the endo- toxin), and ~-interferon (-ยข-IFN). In particular, we thelium of blood vessels involved in local supply focus on our current understanding of the receptors and leukocytes such as neutrophils, macrophages/ for these molecules: their structure, distribution, monocytes, lymphocytes, and platelets, which are, regulation, and signal transduction mechanisms. for the most part, recruited from TI - Human cytokine receptors JF - Journal of Clinical Immunology DO - 10.1007/BF00917473 DA - 2004-12-16 UR - https://www.deepdyve.com/lp/springer-journals/human-cytokine-receptors-5cf35DUnNt SP - 289 EP - 299 VL - 10 IS - 6 DP - DeepDyve ER -