TY - JOUR
AU1 - Liu, Jin
AU2 - Zhu, Mingyi
AU3 - Tang, Qianli
AB - ObjectiveIt has been studied that mesenchymal stem cells (MSCs)-derived exosomes could suppress tumor growth in nasopharyngeal carcinoma (NPC) and microRNA-181a (miR-181a) could mediate drug resistance in NPC. Focused on this work, the mechanism of human umbilical cord MSCs (hUC-MSCs)-derived exosomal miR-181a was explored in NPC cell progression.MethodsNPC tissues and normal tissues were obtained from patients, and miR-181a and KDM5C expression was examined. hUC-MSCs-derived exosomes were extracted, identified and co-cultured with NPC cells (C666-1 and SUNE1). C666-1 cell progression in vitro and/or tumor growth in vivo were examined after incubation with exosomes, miR-181a or lysine-specific demethylase 5C (KDM5C). miR-181a and KDM5C expression were examined in NPC.ResultsmiR-181a expression was reduced while KDM5C expression was elevated in NPC. hUC-MSCs-derived exosomes restrained NPC cell growth in vivo and in vitro. Depleting or restoring exosomal miR-181a promoted or delayed NPC cell progression. KDM5C silencing suppressed NPC cell progression.ConclusionThis study concluded that hUC-MSCs-derived exosomal miR-181a retards NPC development via negatively modulating KDM5C, serving as a candidate reference for the therapy of NPC.
TI - Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-181a retards nasopharyngeal carcinoma development by mediating KDM5C
JF - Journal of Cancer Research and Clinical Oncology
DO - 10.1007/s00432-021-03684-6
DA - 2021-10-01
UR - https://www.deepdyve.com/lp/springer-journals/human-umbilical-cord-mesenchymal-stem-cells-derived-exosomal-microrna-5cSAzliHxl
SP - 2867
EP - 2877
VL - 147
IS - 10
DP - DeepDyve
ER -