TY - JOUR
AU1 - Ruth K. Globus, Emily Morey-Holton
AB - Abstract The rodent hindlimb unloading (HU) model was developed in the 1980s to make it possible to study mechanisms, responses, and treatments for the adverse consequences of spaceflight. Decades before development of the HU model, weightlessness was predicted to yield deficits in the principal tissues responsible for structure and movement on Earth, primarily muscle and bone. Indeed, results from early spaceflight and HU experiments confirmed the expected sensitivity of the musculoskeletal system to gravity loading. Results from human and animal spaceflight and HU experiments show that nearly all organ systems and tissues studied display some measurable changes, albeit sometimes minor and of uncertain relevance to astronaut health. The focus of this review is to examine key HU results for various organ systems including those related to stress; the immune, cardiovascular, and nervous systems; vision changes; and wound healing. Analysis of the validity of the HU model is important given its potential value for both hypothesis testing and countermeasure development. spaceflight hindlimb unloading gravity physiology adaptation View Full Text Previous Next Back to top About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Ed Board (PDF) Article Abstract GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Applied Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Hindlimb unloading: rodent analog for microgravity Message Subject (Your Name) has sent you a message from Journal of Applied Physiology Message Body (Your Name) thought you would like to see the Journal of Applied Physiology web site. Your Personal Message Print Citation Tools Hindlimb unloading: rodent analog for microgravity Ruth K. Globus , Emily Morey-Holton Journal of Applied Physiology May 2016, 120 (10) 1196-1206; DOI: 10.1152/japplphysiol.00997.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Ruth K. Globus , Emily Morey-Holton Journal of Applied Physiology May 2016, 120 (10) 1196-1206; DOI: 10.1152/japplphysiol.00997.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Parabolic flight as a spaceflight analog Effects of isolation and confinement on humans-implications for manned space explorations Pressure distension in leg vessels as influenced by prolonged bed rest and a pressure habituation regimen Show more Highlighted Topic Related Articles No related articles found. Web of Science PubMed Google Scholar Cited By... No citing articles found. Web of Science (1) Google Scholar Most Cited Most Read A new method for detecting anaerobic threshold by gas exchange Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. 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TI - Hindlimb unloading: rodent analog for microgravity
JF - Journal of Applied Physiology
DO - 10.1152/japplphysiol.00997.2015
DA - 2016-05-15
UR - https://www.deepdyve.com/lp/the-american-physiological-society/hindlimb-unloading-rodent-analog-for-microgravity-5V0gEXChl8
SP - 1196
VL - 120
IS - 10
DP - DeepDyve
ER -