TY - JOUR
AB - Abstract To the Editor.— Fibronectin (FN) is a glycoprotein that functions as a biological adhesive and mediates bonding between a variety of cell types and their extracellular matrices.1 Recent studies have shown that topical application of FN eyedrops is an effective therapeutic approach for resolving nonhealing ulcers of the corneal epithelium after herpetic keratitis2 and keratoconjunctivitis sicca.3Unlike the basal keratinocytes of unwounded skin that are attached to a basement membrane containing laminin and type IV collagen,4 keratinocytes that reepithelialize a wound bed move over/through an FN-rich matrix5,6 that lacks laminin and type IV collagen.7 Fibronectin promotes keratinocyte adhesion, motility, and phagocytosis.8-10 Also, a transient activation of keratinocyte adhesion to FN was observed during repair of full-thickness wounds in an animal model.11 Moreover, activation of keratinocyte adhesion has been found to be selective for FN relative to other matrix components, including collagen type I References 1. Yamada KM: Cell surface interactions with extracellular materials . Ann Rev Biochem 1983;52:761-799.Crossref 2. Nishida T, Nakagawa S, Manabe R: Clinical evaluation of fibronectin eyedrops on epithelial disorders after herpetic keratitis . Ophthalmology 1985;92:213-216.Crossref 3. Kono I, Matsumoto Y, Kano K, et al: Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of Sjögren's syndrome . J Rheumatol 1985;12:487-489. 4. Katz SI: The epidermal basement membrane zone . JAm Acad Dermatol 1984;11:1025-1037.Crossref 5. Grinnell F, Billingham RE, Burgess L: Distribution of fibronectin during wound healing in vivo . J Invest Dermatol 1981;76:181-189.Crossref 6. Clark RAF, Lanigan JM, DellaPelle P, et al: Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization . J Invest Dermatol 1982;79:264-269.Crossref 7. Stanley JR, Alvarez OM, Bere EW, et al: Detection of basement membrane zone antigens during epidermal wound healing in pigs . J Invest Dermatol 1981;77:240-243.Crossref 8. Stenn KS, Madri JA, Tinghitella T, et al: Multiple mechanisms of dissociated epidermal cell spreading . J Cell Biol 1984;96:63-67.Crossref 9. Takashima A, Grinnell F: Human keratinocyte adhesion and phagocytosis promoted by fibronectin . J Invest Dermatol 1984; 83:352-358.Crossref 10. O'Keefe EJ, Payne RE, Russell N, et al: Spreading and enhanced motility of human keratinocytes on fibronectin . J Invest Dermatol 1985;85:125-130.Crossref 11. Takashima A, Billingham RE, Grinnell F: Activation of rabbit keratinocyte fibronectin receptor function in vivo during wound healing . J Invest Dermatol 1986;86:585-590.Crossref 12. Toda K-I, Grinnell F: Activation of human keratinocyte fibronectin receptor function in relationship to other ligand-receptor interactions . J Invest Dermatol 1987;88:412-417.Crossref 13. Horowitz B, Wiebe ME, Lippin A, et al: Inactivation of viruses in labile blood derivatives: I. Disruption of lipid-enveloped viruses by tri(normal-butyl)phosphate detergent combinations . Transfusion 1985;25:516-522.Crossref 14. United States Public Health Service: Detailed Diagnoses and Surgical Procedures for Patients Discharged From Short-Stay Hospitals (United States, 1979) , Department of Health and Human Services Publication, 1982, No. (82-1274-1) .
TI - Topical Fibronectin Therapy for Treatment of a Patient With Chronic Stasis Ulcers
JO - Archives of Dermatology
DO - 10.1001/archderm.1988.01670020007002
DA - 1988-02-01
UR - https://www.deepdyve.com/lp/american-medical-association/topical-fibronectin-therapy-for-treatment-of-a-patient-with-chronic-5G4Wdpdlhu
SP - 175
EP - 177
VL - 124
IS - 2
DP - DeepDyve
ER -