TY - JOUR
AU - Woodard, John S.
AB - Abstract The observation of granulovacuoles in the hippocampal pyramidal neurons in cases of senile dementia was made at the turn of the century, but the extent to which the abnormality is specific and of diagnostic value in morphologic classification has not been clearly established. An analysis of the abnormality in a series of 200 unselected autopsies on patients with all forms of mental disease is presented. Granulovacuolar degeneration among the hippocampal neurons is a constant finding in Alzheimer's disease which lends itself to easy recognition and quantitation using routine staining methods. With approximate quantitation the abnormal feature has sufficient specificity to be of diagnostic value, and, in contrast to more commonly used morphologic criteria, granulovacuolar degeneration retains its specificity for the clinical manifestations of Alzheimer's disease throughout the “senile” age period. This content is only available as a PDF. Author notes * From the Neuropathology Research Laboratory, Camarillo State Hospital, Camarillo, California. † This study was supported by a California Department of Mental Hygiene Grant-in-aid #58-5.3#7. Copyright, 1962 by the Association of the Journal of Neuropathology and Experimental Neurology, Inc.
TI - Clinicopathologic Significance of Granulovacuolar Degeneration in Alzheimer's Disease
JF - Journal of Neuropathology & Experimental Neurology
DO - 10.1097/00005072-196201000-00007
DA - 1962-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/clinicopathologic-significance-of-granulovacuolar-degeneration-in-5FDh2c8s3I
SP - 85
EP - 91
VL - 21
IS - 1
DP - DeepDyve
ER -