TY - JOUR
AU - Merry, A.H.
AB - Phagocytosis was investigated using human peripheral monocytes and erythrocytes sensitized withknown amounts of subclass-specific IgG anti-Rh antibodies. The erythrocyte-bound IgG was quantitated by aradiometric antiglobulin test. This evaluation revealed the following: (1) there is a relationship between phagocytosisand the number of erythrocyte-bound IgG molecules; (2) phagocytosis is IgG subclass-dependent, since a similardegree of phagocytosis is observed with fewer IgG3 than IgG1 molecules and also the minimum number of IgG3molecules for phagocytosis is 150-640, whilst for IgGl the minimum is 1,230-4,020; (3) the minimum levels ofsensitization for phagocytosis should be detectable by the serological antiglobulin test; (4) the phagocytosis assay isno more sensitive than the monocyte rosette assay for the detection of anti-Rh alloantibodies, and (5) phagocytosis ofadherent erythrocytes observed by video-enhanced microscopy indicated that erythrocytes may adhere to monocytesfor a considerable time before phagocytosis, but that phagocytosis itself was rapid.
TI - Phagocytosis of Erythrocytes Sensitized with Known Amounts of IgG1 and IgG3 Anti-Rh Antibodies
JF - Vox Sanguinis
DO - 10.1159/000461705
DA - 2017-01-01
UR - https://www.deepdyve.com/lp/karger/phagocytosis-of-erythrocytes-sensitized-with-known-amounts-of-igg1-and-5E4GYNUwuF
SP - 96
EP - 101
VL - 53
IS - 2
DP - DeepDyve
ER -