TY - JOUR
AU1 - Bang, Gisle
AU2 - Urist, Marshall R.
AB - Abstract EXPERIMENTS by Charles B. Huggins and his associates,1 and many others during the past thirty years,2-11 demonstrate that whole toothbuds and parts of toothbuds possess the capacity to grow and develop in areas of the body other than the jawbone, even in the form of explants in tissue culture. The toothbud not only continues its characteristic development, but also exhibits the capacity to induce undifferentiated connective tissues to form bone. To explain these observations, Hoffman12 postulates that the enamel organ and its derivative, Hertwig's epithelial root sheath, stimulates connective tissue cells to differentiate into bone cells, while Zussman13 contends that odontoblasts which had previously participated in dentin formation can produce bone even when not in contact with oral tissues. Except that the new bone originates from proliferating living cells in both the transplanted tooth and in the host bed, present knowledge of the local physiology of References 1. Huggins, C.B.; McCarroll, H.R.; and Dahlberg, A.A.: Transplantation of Tooth Germ Elements and the Experimental Heterotopic Formation of Dentine and Enamel , J Exp Med 60:199-210, 1934.Crossref 2. Pinkerton, H., and Boyle, P.E.: Cultivation in Vitro of Tissues Removed From the Enamel Organ and Dental Pulp , J Dent Res 15:221, 1935. 3. Glasstone, S.: Development of Tooth Germs in Vitro , J Anat 70:260-266, 1936. 4. Losee, F.L.: Method of Growing the Rat Tooth Germ "in Vitro," Using the Depression Slide , US Naval Med Bull 41:758-763, 1943. 5. Fleming, H.S.: Homologous and Heterologous Intraocular Growth of Transplanted Tooth Germs , J Dent Res 31:166-188, 1952.Crossref 6. Glasstone, S.: The Development of Tooth Germs on the Chick Chorio-Allantois , J Anat 88:392-399, 1954. 7. Lefkowitz, W.; Mardfin, D.F.; and Bodecker, C.F.: Cultivation of Rat Molar Tooth Germs in Carrel Flasks , J Dent Res 33:189-200, 1954.Crossref 8. Szabo, G.: Studies on the Cultivation of Teeth in Vitro , J Anat 88:31-44, 1954. 9. Hay, M.F.: The Development in Vivo and in Vitro of the Lower Incisor and Molars of the Mouse , Arch Oral Biol 3:86-109, 1961.Crossref 10. Fleming, H.S.: The Osteogenic Tendency of Dentin After Formation in Tooth Germ Transplants , Oral Surg 6:1315-1324, 1953.Crossref 11. Fleming, H.S.: Experimental Transplantation of Teeth in Lower Animals , Oral Surg 9:3-17, 1956.Crossref 12. Hoffman, R.L.: Formation of Periodontal Tissues Around Subcutaneously Transplanted Hamster Molars , J Dent Res 39:781-798, 1960.Crossref 13. Zussman, W.V.: Osteogenic Activity of Odontoblasts in Transplanted Tooth Pulps , J Dent Res 45:144-151, 1966.Crossref 14. Urist, M.R., and McLean, F.C.: Osteogenetic Potency and New-Bone Formation by Induction in Transplants to the Anterior Chamber of the Eye , J Bone Joint Surg 34A:443-470, 1952. 15. Urist, M.R.: Bone: Formation by Autoinduction , Science 150:893-899, 1965.Crossref 16. van de Putte, K.A., and Urist, M.R.: Osteogenesis in the Interior of Intramuscular Implants of Decalcified Bone Matrix , Clin Orthop Rel Res 43:257-270, 1965.Crossref 17. Lefkowitz, W., and Mardfin, D.F.: Dissection of Rat Molar Tooth Germs , J Dent Res 33:201-205, 1954.Crossref 18. Russell, P.S., and Monaco, A.P.: The Biology of Tissue Transplantation , Boston: Little, Brown and Company, 1965, p 4.
TI - Bone Induction in Excavation Chambers in Matrix of Decalcified Dentin
JF - Archives of Surgery
DO - 10.1001/archsurg.1967.01330120035008
DA - 1967-06-01
UR - https://www.deepdyve.com/lp/american-medical-association/bone-induction-in-excavation-chambers-in-matrix-of-decalcified-dentin-53R0XHfY3N
SP - 781
EP - 789
VL - 94
IS - 6
DP - DeepDyve
ER -