TY - JOUR
AU - Seder, David
AB - Neurocrit Care (2017) 27:334–340 DOI 10.1007/s12028-017-0422-7 ORIGINAL ARTICLE Low-dose Prothrombin Complex Concentrate for Warfarin- Associated Intracranial Hemorrhage with INR Less Than 2.0 1 1 1 2 • • • • Wesley R. Zemrak Kathryn E. Smith Stephen S. Rolfe Teresa May 3 4 5 • • • Robert L. Trowbridge Timothy L. Hayes Gene A. Grindlinger David B. Seder Published online: 28 June 2017 Springer Science+Business Media, LLC 2017 Abstract check following dosing and 17/20 (85%) achieved an INR Background Prothrombin complex concentrates (PCCs) value B1.3. One patient did not have follow-up INR testing have become the first-line therapy for warfarin reversal in due to withdrawal of life support. No patient experienced the setting of central nervous system (CNS) hemorrhage. hematoma expansion within 48 h of 4F-PCC, and there Randomized, controlled studies comparing agents for were no thromboembolic events within 72 h of warfarin reversal excluded patients with international nor- administration. malized ratio (INR) <2, yet INR values of 1.6–1.9 are also Conclusions The administration of low dose (15 units/kg) associated with poor outcomes. of 4F-PCC for urgent warfarin reversal in the setting of Methods We retrospectively reviewed our use of a low- CNS hemorrhage was effective in correcting 
TI - Low-dose Prothrombin Complex Concentrate for Warfarin-Associated Intracranial Hemorrhage with INR Less Than 2.0
JF - Neurocritical Care
DO - 10.1007/s12028-017-0422-7
DA - 2017-06-28
UR - https://www.deepdyve.com/lp/springer-journals/low-dose-prothrombin-complex-concentrate-for-warfarin-associated-4sIHajI35a
SP - 334
EP - 340
VL - 27
IS - 3
DP - DeepDyve
ER -