TY - JOUR
AU - Hashizume, Yoshio
AB - Purpose The purpose of this study is to clarify the characteristic structural magnetic resonance imaging (MRI) findings in demented patients with pathologically confirmed argyrophilic grain disease (AGD). Methods Nine pathologically confirmed AGD patients with cerebral three-dimensional T1-weighted MRI were evaluated in this study. In addition to visual rating scales of atrophic and asymmetric changes in the limbic and temporal lobes, voxel-based morphom- etry (VBM) was performed to assess group difference between pathologically confirmed AGD and Alzheimer’s disease (AD) patients. Results On visual analyses of AGD patients, the medial temporal, anterior temporal, and posterior temporal atrophy scores were 3.3 ± 0.7, 1.7 ± 0.5, and 1.0 ± 0.7, respectively. Asymmetric scores of the hippocampus and parahippocampal gyrus, amygdala and ambient gyrus, anterior temporal, and posterior temporal lobes were rated as 1.1 ± 0.7, 1.6 ± 0.5, 1.3 ± 0.8, and 0.4 ± 0.7, respectively. In spite of no statistical differences in atrophic scores, AGD patients showed the higher score and proportion of anterior temporal asymmetric score than AD (p = 0.03 and 0.02). Compared with controls, VBM analysis revealed left dominant asymmetric atrophy predominantly in the limbic and anterior temporal lobe in AGD patients. By contrast, there was no signif- 
TI - Characteristic asymmetric limbic and anterior temporal atrophy in demented patients with pathologically confirmed argyrophilic grain disease
JF - Neuroradiology 0028-3940
DO - 10.1007/s00234-019-02247-4
DA - 2019-06-29
UR - https://www.deepdyve.com/lp/springer-journals/characteristic-asymmetric-limbic-and-anterior-temporal-atrophy-in-4amH523QTo
SP - 1239
EP - 1249
VL - 61
IS - 11
DP - DeepDyve
ER -