TY - JOUR
AU - SOLOMON,, SAMUEL
AB - The role of isoproterenol in the synthesis of heme associated with hemoglobin has been studied in primary cultures of human fetal liver. This drug (10‒10M) stimulated the incorporation of 59Fe into heme associated with hemoglobin in cell cultures of livers obtained from human fetuses 8 to 10 weeks gestation but was inactive in cell cultures prepared from livers of older fetuses. Isoproterenol has its optimal activity at a much earlier time in gestation than that previously reported for testosterone or erythropoietin. The interpretation of these results is that there is present a cell population in human fetal liver early in gestation with the appropriate isoproterenolreceptors and capable of erythroid differentiation after exposure to the drug. (Endocrinology100: 1303, 1977) This content is only available as a PDF. Copyright © 1977 by The Endocrine Society
TI - Isoproterenol Stimulation of Heme Synthesis in Cultures of Human Fetal Liver from Early Gestation
JF - Endocrinology
DO - 10.1210/endo-100-5-1303
DA - 1977-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/isoproterenol-stimulation-of-heme-synthesis-in-cultures-of-human-fetal-4Rx6Ac0GgR
SP - 1303
EP - 1305
VL - 100
IS - 5
DP - DeepDyve
ER -