TY - JOUR
AU1 - Dalmas, Elise
AB - Growing evidence suggests that components of the innate immune system play a crucial role in regulating metabolic homeostasis. Macrophages were the primary immune cells to be described in both the white adipose tissue and the pancreatic islets. Therein, their functions, beneficial or detrimental, are extending under steady state and in the context of obesity-induced type 2 diabetes. Other populations, including innate lymphoid cells, are emerging as key sentinels of metabolic tissues and privileged partners of macrophages. The present review will thus explore the phenotype and the role of innate immune cells in metabolic physiology and dysfunction. Discussion will tackle pending questions and future perspectives in the field of immunometabolism. . . . . . Keywords Metabolism Diabetes Immunity Insulin Macrophages Innate lymphoid cells Introduction have become key features of enlarged adipose tissue [2]. This local inflammation is associated with a marked accumu- In physiology, immune cells reside in all organs, including lation of macrophages within the adipose tissue, especially in metabolic tissues. The immune system is now recognized as the intra-abdominal depot, during the course of obesity [3, 4]. a major regulator of metabolism, a function not related to More recently, macrophages were also shown to reside inside classical 
TI - Role of innate immune cells in metabolism: from physiology to type 2 diabetes
JF - Seminars in Immunopathology
DO - 10.1007/s00281-019-00736-5
DA - 2019-04-05
UR - https://www.deepdyve.com/lp/springer-journals/role-of-innate-immune-cells-in-metabolism-from-physiology-to-type-2-4Kh2tN6Ebf
SP - 1
EP - 15
VL - OnlineFirst
IS - 
DP - DeepDyve
ER -