TY - JOUR
AU1 - Speck, Ana
AU2 - Fraga, Daiane
AU3 - Soares, Priscila
AU4 - Scheffer, Débora
AU5 - Silva, Luciano
AU6 - Aguiar, Aderbal
AU7 - Estreck, Emílio
AU8 - Pinho, Ricardo
AB - Physical exercise and smoking are environmental factors that generally cause opposite health-promoting adaptations. Both physical exercise and smoking converge on mitochondrial adaptations in various tissues, including the pro-oxidant nervous system. Here, we analyzed the impact of cigarette smoking on exercise-induced brain mitochondrial adaptations in the hippocampus and pre-frontal cortex of adult mice. The animals were exposed to chronic cigarette smoke followed by 8 weeks of moderate-intensity physical exercise that increased mitochondrial activity in the hippocampus and pre-frontal cortex in the non-smoker mice. However, mice previously exposed to cigarette smoke did not present these exercise-induced mitochondrial adaptations. Our results suggest that smoking can inhibit some brain health-promoting changes induced by physical exercise.
TI - Cigarette Smoke Inhibits Brain Mitochondrial Adaptations of Exercised Mice
JF - Neurochemical Research
DO - 10.1007/s11064-011-0447-9
DA - 2011-03-22
UR - https://www.deepdyve.com/lp/springer-journals/cigarette-smoke-inhibits-brain-mitochondrial-adaptations-of-exercised-3kj9vGfnK4
SP - 1056
EP - 1061
VL - 36
IS - 6
DP - DeepDyve
ER -