TY - JOUR
AU1 - Kutyrina, I., M.
AU2 - Nikishova, T., A.
AU3 - Tareyeva, I., E.
AB - Abstract The effects of heparin-induced aldosterone deficiency on renal sodium and potassium transport and renal function were studied in 65 patients with chronic glomerulonephritis and initial hyperaldosteronism. Heparin-induced aldosterone deficiency resulted in increased diuresis, in natriuresis due to decreased sodium reabsorption in the distal nephron, in a fall in serum sodium and an increase in serum potassium concentration. A transient reduction in potassium excretion occurred during the 2–4 days of heparin treatment. In patients with chronic glomerulonephritis and a compromised renin–angiotensin–aldosterone system, heparin may cause drug-induced selective hypoaldosteronism. The suppressive effect of heparin on aldosterone production was partially compensated for by increasing plasma renin activity. Heparin-induced aldosterone deficiency did not change glomerular filtration rate in patients without renal failure. In those with chronic sclerosing glomerulonephritis and a glomerular filtration rate less than 35 ml/min, heparin caused a further decrease in renal function. Heparin, Plasma renin activity, Plasma and urine aldosterone, Selective hypoaldosteronism, Sodium excretion This content is only available as a PDF. © 1987 European Dialysis and Transplant Association-European Renal Association
TI - Effects of Heparin-Induced Aldosterone Deficiency on Renal Function in Patients with Chronic Glomerulonephritis
JF - Nephrology Dialysis Transplantation
DO - 10.1093/oxfordjournals.ndt.a091545
DA - 1987-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/effects-of-heparin-induced-aldosterone-deficiency-on-renal-function-in-3WWsoSNNtx
SP - 219
EP - 223
VL - 2
IS - 4
DP - DeepDyve
ER -