TY - JOUR
AU - Gross, W. L.
AB - Rheumatology 2008;47:1111–1113 doi:10.1093/rheumatology/ken202 Advance Access publication 31 May 2008 Editorial Germinal centre-like structures in Wegener’s granuloma: the morphological basis for autoimmunity? Wegener’s granulomatosis (WG) shows a unique dual morphology (neutrophils, monocytes) surrounded by antigen-presenting cells in comprising a vasculitis as well as extravascular granuloma- (e.g. CD208 DCs) as well as effector T cells, expressing the tous inflammation. Together with the much rarer Churg–Strauss activating receptor NKG2D [6]. These NKG2Dþ cells could syndrome, WG is the only primary systemic vasculitis that features bind to cells expressing the NKG2D ligand, MIC (MHC class I a salient extravascular inflammatory component. While the patho- related chain) [22], promoting a self-perpetuating inflammatory physiology of ANCA-induced endothelial vessel wall damage has and autoimmune response in the tissue. been well studied (for review see [1]), more recent data described Since the tertiary lymphatic structures can develop during the formation of lymphatic follicles in granulomatous lesions and infectious conditions [17], one of the open questions is if the their potential role for the generation of ANCA against Wegener’s germinal centre-like structures in the WG granuloma might be autoantigen proteinase 3 (PR3-ANCA) [2, 3]. Further, an intricate initially formed in order to eliminate an infectious pathogen. interplay between 
TI - Germinal centre-like structures in Wegener's granuloma: the morphological basis for autoimmunity?
JO - Rheumatology
DO - 10.1093/rheumatology/ken202
DA - 2008-08-31
UR - https://www.deepdyve.com/lp/oxford-university-press/germinal-centre-like-structures-in-wegener-s-granuloma-the-3RbKY6ugnC
SP - 1111
EP - 1113
VL - 47
IS - 8
DP - DeepDyve
ER -