TY - JOUR
AU - Taylor, E P
AB - REVIEW ARTICLE QUATERNARY AMMONIUM COMPOUNDS IN MEDICINAL CHEMISTRY. I* BY P. F. D’ARcY, B.Pharm., Ph.D., M.P.S. and E. P. TAYLOR, B.Pharm., B.Sc., Ph.D., F.R.I.C. The Research Division, Allen & Hanburys Limited, Ware, Hertfordshire INTEREST in the biological activity of quaternary ammonium salts stems from the elegant work of Crum Brown and Fraser (1868-9), who were the first to record the curariform activity of methiodides of alkaloids such as strychnine, brucine, and atropine. Apart from a few scattered papers, the pharmacological activity of quaternary ammonium salts received little attention for many years. Hunt, Renshaw and their associates, working over a period of some 35 years from 1904 to 1939, published a very large number of papers dealing with the effects of these compounds on the autonomic nervous system ; they established three basic types of activity, muscarinic, nicotinic and curariform. References to this work are listed in full in Craig’s excellent review, “Curariform activity and chemical structure” (1948). Concurrently with these studies, quaternary ammonium compounds were emerging into greater prominence by virtue of their activity against micro-organisms. Their germicidal activity was first recognised in 1916, when Jacobs and his colleagues (Jacobs, 1916; Jacobs, Heidelberger and Amoss, 1916 ; Jacobs, Heidelberger 
TI - Quaternary Ammonium Compounds in Medicinal Chemistry. I*
JF - Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science
DO - 10.1111/j.2042-7158.1962.tb11069.x
DA - 1962-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/quaternary-ammonium-compounds-in-medicinal-chemistry-i-3M0SimHVEK
SP - 129
EP - 146
VL - 14
IS - 1
DP - DeepDyve
ER -