TY - JOUR
AU - Wolf, George
AB - specific proteins in the nucleus act as transcription factors upon activation through binding of small molecules (all-trans-retinoic acid, thyroid hormone, vitamin D, and others). The activated (liganded) receptors bind to specific DNA elements as heterodimers, each in combination with the retinoic acid-X receptor (RXR). 9-Cis-retinoic acid binds to RXR with high affinity and activates it. Though 9-cis-retinoic acid was initially found in animal tissues, in later work 9-cis-retinoic acid could not be detected. A search for a ligand for RXR in tissues showed that unsaturated fatty acids, particularly linoleic, linolenic, and docosahexaenoic acids, bound to and activated RXR as specific ligands, although with low affinity. A critical experiment demonstrated that, at least in developing mouse skin, 9-cis-retinoic acid is not the ligand for RXR
TI - Is 9-Cis-Retinoic Acid the Endogenous Ligand for the Retinoic Acid-X Receptor?
JO - Nutrition Reviews
DO - 10.1111/j.1753-4887.2006.tb00186.x
DA - 2006-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/is-9-cis-retinoic-acid-the-endogenous-ligand-for-the-retinoic-acid-x-3K5O0UG355
SP - 532
EP - 538
VL - 64
IS - 12
DP - DeepDyve
ER -