TY - JOUR
AU - Domb, Abraham J.
AB - Injectable polymeric systems suitable for the localized delivery of anticancer agents are reviewed. These polymeric systems include: drug‐loaded low melting temperature polymers that are injected at the melting temperature of the polymer, usually below 50 °C, that solidify at body temperature to form an in situ device; polymer solutions in buffer or in N‐methyl pyrrolidone, ethanol, or acetate esters which, upon injection in tissue,are absorbed into the tissue and cause precipitation of the polymer at the injection site; in situ crosslinking of polymer solutions to form a polymeric implant; and thermoresponsive polymer solutions that are soluble at room temperature and solidify at body temperature. However, these systems are hydrophilic and suffer from burst release of drug within a few hours post injection. Hydrophobic injectable, pasty, fat‐based polymers that gel when injected in tissue have been used for the extended release of paclitaxel, cisplatin, and other agents. This polymer releases the drug in a controlled manner with no burst release. These systems have a potential use as drug carriers for regional or systemic drug delivery.
TI - Pasty Polymers in Cancer Drug Therapy
JF - Israel Journal of Chemistry
DO - 10.1002/ijch.201000027
DA - 2010-08-01
UR - https://www.deepdyve.com/lp/wiley/pasty-polymers-in-cancer-drug-therapy-39gV6lFc9r
SP - 233
EP - 238
VL - 50
IS - 2
DP - DeepDyve
ER -