TY - JOUR
AU - Bienz, Stefan
AB - The reaction mechanism of the LiH addition to α‐chiral ketones and acylsilanes was calculated at the ab initio MP2/6‐311+G**//RHF/6‐31G* level. The selectivities predicted on the basis of the computed transition states and reaction barriers compare well with the experimental data. For compounds possessing very large groups, anti‐Cram selectivity was found; silicon‐containing compounds should show the same types of selectivity as their carbon analogs. The calculations suggest that a revision of the Felkin−Anh model is necessary and a proposal for such a revision is given. (© Wiley‐VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
TI - The Cram Rule Revisited Once More — Revision of the Felkin−Anh Model
JF - European Journal of Organic Chemistry
DO - 10.1002/1099-0690(200208)2002:16<2770::AID-EJOC2770>3.0.CO;2-X
DA - 2002-08-01
UR - https://www.deepdyve.com/lp/wiley/the-cram-rule-revisited-once-more-revision-of-the-felkin-anh-model-2wZD0zAQNw
SP - 2770
EP - 2775
VL - 2002
IS - 16
DP - DeepDyve
ER -