TY - JOUR AU - AB - Background: Inuenza places a signicant burden on global health and economics. Individual case management and public health efforts to mitigate the spread of inuenza are both strongly impacted by our ability to accurately and e ciently detect inuenza viruses in clinical samples. Therefore, it is important to understand the performance characteristics of available assays to detect inuenza in a variety of settings. We provide the rst report of relative performance between two products marketed to streamline detection of inuenza virus in the context of a highly controlled volunteer inuenza challenge study. Methods: Nasopharyngeal swab samples were collected during a controlled A/California/2009/H1N1 inuenza challenge study and analyzed using for detection of virus shedding using a validated qRT-PCR (qPCR) assay, a sample-to-answer qRT-PCR device (BioMerieux BioFire FilmArray RP), and an immunoassay based rapid test kit (Quidel QuickVue Inuenza A+B Test). Results: Relative to qPCR, the sensitivity and specicity of the BioFire assay was 72.1% (63.7%-79.5%, 95% Condence Interval (CI)) and 93.5% (89.3%-96.4%, 95% CI) respectively. For the QuickVue rapid test the sensitivity was 8.5% (4.8%-13.7%, 95% CI) and specicity was 99.2% (95.6%-100%, 95% CI). Conclusion: Relative to qPCR, the BioFire assay had superior performance compared to rapid test in the context TI - Performance of BioFire Array or QuickVue Influenza A+B Test versus a validation qPCR assay for detection of influenza A during a volunteer A/California/2009/H1N1 challenge study DO - 10.21203/rs.3.rs-22980/v1 DA - 2020-04-23 UR - https://www.deepdyve.com/lp/unpaywall/performance-of-biofire-array-or-quickvue-influenza-a-b-test-versus-a-2w7DVLhg0U DP - DeepDyve ER -