TY - JOUR
AU - Zhang, Yonghong
AB - Introduction Ischemic stroke (IS) is a major contributor to the global disease burden, and effective biomarkers for IS management in clinical practice are urgently needed. Metabolomics can detect metabolites that are small enough to cross the blood–brain barrier in a high-throughput manner, and thus represents a powerful tool for discovering biomarkers of IS. Objectives In this study, we conducted a systematic review to identify potential metabolic biomarkers and pathways that might facilitate risk predictions, clinical diagnoses, the recognition of complications, predictions of recurrence and an understanding of the pathogenesis of IS. Methods The PubMed and Web of Science databases were searched for relevant studies published between January 2000 and July 2019. The study objectives, study designs and reported metabolic biomarkers were systematically examined and compared. Pathway analysis was performed using the MetaboAnalyst online software. Results Twenty-eight studies were included in this systematic review. Many consistent metabolites, including isoleucine, leucine, valine, glycine, lysine, glutamate, LysoPC(16:0), LysoPC(18:2), serine, uric acid, citrate and palmitic acid, possess potential as biomarkers of IS. Metabolic pathways and dysregulations that are implicated in excitotoxicity, inflammation, 2+ apoptosis, oxidative stress, neuroprotection, energy failure, and elevation of intracellular Ca levels, were indicated as play- ing important roles in 
TI - Metabolomics facilitates the discovery of metabolic biomarkers and pathways for ischemic stroke: a systematic review
JF - Metabolomics
DO - 10.1007/s11306-019-1615-1
DA - 2019-11-21
UR - https://www.deepdyve.com/lp/springer-journals/metabolomics-facilitates-the-discovery-of-metabolic-biomarkers-and-2fVwAgJjlv
SP - 1
EP - 21
VL - 15
IS - 12
DP - DeepDyve
ER -