TY - JOUR
AU - Hill, Matthew J.
AB - Schizophrenia Bulletin vol. 42 no. 1 pp. 5–8, 2016 doi:10.1093/schbul/sbv156 Advance Access publication November 4, 2015 GENES AND SCHIZOPHRENIA Nicholas J. Bray* and Matthew J. Hill MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, UK *To whom correspondence should be addressed; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK; tel: +44-(0)2920-688368, fax: +44-(0)2920-687068, e-mail: BrayN3@cardiff.ac.uk Introduction actual susceptibility genes at these loci (ie, those that are functionally altered by the risk variants) have been confi- The past decade has witnessed major advances in our dently identified. One reason for this is that genotypes at understanding of the genetics of schizophrenia. Large, con- neighboring DNA variants often correlate within a pop- sortia-led genomic studies involving thousands of patients ulation (a phenomenon known as “linkage disequilib- and controls have identified genetic loci associated with risk rium”), with the result that association signals can span for the disorder at unprecedented levels of confidence. As large genomic regions, often encompassing more than 1 expected from a condition associated with reduced fecun- gene. In addition, it is now known that genes typically dity, variants that have a large impact 
TI - Translating Genetic Risk Loci Into Molecular Risk Mechanisms for Schizophrenia
JO - Schizophrenia Bulletin
DO - 10.1093/schbul/sbv156
DA - 2016-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/translating-genetic-risk-loci-into-molecular-risk-mechanisms-for-2Qp0bdfWPH
SP - 5
EP - 8
VL - 42
IS - 1
DP - DeepDyve
ER -