TY - JOUR
AU - Symann, Michel
AB - Abstract Transplantation of blood-derived stem cells is increasingly performed because when used alone or when combined with autologous bone marrow grafting, it can demonstrably shorten myelosuppression following multi-agent chemotherapy. Hematopoieric growth factors can mobilize peripheral blood stem cells from the bone marrow to therapeutically intervene in accelerating hematologic recovery. Interleukin 3 (IL-3), whose hematopoietic activities were first described some ten years ago, is one of several candidate growth factors that may prove useful in enhancing this mobilization in order to obtain adequate yields of circulating stem cells for transplantation. IL-3 used in conjunction with synergistically acting cytokines such as granulocyte-macrophage colony stimulating factor (GM-CSF) or granulocyte CSF (G-CSF) have already yielded interesting results, while new factors like stem cell factor are in the process of clinical evaluations and appear promising. 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TI - IL-3 and Peripheral blood stem cell harvesting
JF - Stem Cells
DO - 10.1002/stem.5530110303
DA - 1993-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/il-3-and-peripheral-blood-stem-cell-harvesting-2Qc3zHBsEk
SP - 173
EP - 181
VL - 11
IS - 3
DP - DeepDyve
ER -