TY - JOUR
AU1 - Li, Baoman
AU2 - Zhang,  Shiquen
AU3 - Li,  Min
AU4 - Hertz,  Leif
AU5 - Peng,  Liang
AB - This demonstration replicates the fluoxetine-induced cPLA 2 upregulation in rat brain shown by Rao et al. (Pharmacogenomics J 6:413–420, 2006) and provides the new information that upregulation (1) occurs in astrocytes, (2) is evoked by stimulation of 5-HT 2B receptor, and (3) requires transactivation-mediated ERK 1/2 phosphorylation. Similar upregulation of cPLA 2 in intact brain in response to 5-HT 2 -mediated signaling by elevated serotonin levels and/or an SSRI during antidepressant treatment may explain the repeatedly reported ability of SSRIs to normalize regional decreases which occur in brain metabolism during major depression, since (1) arachidonic acid strongly stimulates glucose metabolism in cultured astrocytes (Yu et al., J Neurosci Res 64:295–303, 1993) and (2) plasma concentrations of arachidonic acid in depressed patients are linearly correlated with regional brain glucose metabolism (Elizabeth Sublette et al., Prostaglandins Leukot Essent Fatty Acids 80:57–64, 2009).
TI - Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA 2 expression secondary to 5-HT 2B -induced, transactivation-mediated ERK 1/2 phosphorylation
JF - Psychopharmacology
DO - 10.1007/s00213-009-1631-3
DA - 2009-11-01
UR - https://www.deepdyve.com/lp/springer-journals/chronic-treatment-of-astrocytes-with-therapeutically-relevant-2FasX1HFdn
SP - 1
EP - 12
VL - 207
IS - 1
DP - DeepDyve
ER -