TY - JOUR
AU1 - Kapmeyer, Wolfgang H.
AU2 - Pauly, Hans‐Erwin
AU3 - Tuengler, Peter
AB - Nephelometry has become a very reliable and convenient method for immunoassays. Recent innovations in polymer chemistry have led to the design of highly sensitive and reproducible immunoassays for the Behring Nephelometer Analyzer. The principle of particle‐enhanced immunoassays has led to the development of new polymer particles. Key advances include the preparation and use of particles with polystyrene cores covered by thin shells with chemically reactive groups. The cores are prepared by emulsion polymerization, giving particles with a well‐defined size. The particle size has been optimized to fulfill the requirements for nephelometric analysis. The shells consist of a polystyrene/polymethacrylate/polymethacrylamidoacet‐aldehyde dipentylacetal copolymer, which allows a covalent binding of the immunochemicals of interest. Using these particles, a method for the determination of C‐reactive protein has been worked out.
TI - Automated nephelometric immunoassays with novel shell/core particles
JF - Journal of Clinical Laboratory Analysis
DO - 10.1002/jcla.1860020203
DA - 1988-01-01
UR - https://www.deepdyve.com/lp/wiley/automated-nephelometric-immunoassays-with-novel-shell-core-particles-27Wx6ncNi8
SP - 76
EP - 83
VL - 2
IS - 2
DP - DeepDyve
ER -