TY - JOUR
AU - Sesso, Howard D.
AB - BackgroundAlthough basic research has implicated abnormal glucose metabolism in the pathogenesis of hypertension (HTN), epidemiologic studies are limited.MethodsWe assessed whether baseline hemoglobin A1c (HbA1c) was prospectively associated with HTN in the Women’s Health Study (WHS). We analyzed 19,858 women initially free of HTN, diabetes, and cardiovascular disease (CVD) with baseline blood samples. We considered quintiles and clinical cutpoints of HbA1c for the risk of HTN, defined as either a new physician diagnosis, the initiation of antihypertensive treatment, or systolic blood pressure (SBP) ≥140 or diastolic blood pressure (DBP) ≥90 mm H g.ResultsDuring a median follow-up of 11.6 years, 9,408 (47.5%) womendeveloped HTN. In models adjusted for traditional cardiovascularrisk factors, the hazard ratios (HRs) from the lowest (<4.8%, referent)to the highest (≥5.2%) quintile of HbA1c were 1.0 (referent), 0.99,1.06, 1.08, and 1.21 (P, linear trend <0.0001). However, additionaladjustment for body mass index (BMI) eliminated the relation(extreme quintile comparison HR 1.04; P, linear trend 0.10). For clinicalcutpoints, a similar pattern emerged although a positive associationbetween HbA1c and HTN remained in the highest category.ConclusionsHbA1c in women without diabetes was associated with an increased risk of HTN in models controlling for the majority of traditional HTN and coronary risk factors, but this relation was no longer significant after adjustment for BMI. These findings underscore the need for additional studies to delineate the important inter-relationships between glycemia and adiposity with the risk of HTN in other study populations.American Journal of Hypertension advance online publication 9 December 2010; doi:10.1038/ajh.2010.233
TI - Hemoglobin A1c, Body Mass Index, and the Risk of Hypertension in Women
JF - American Journal of Hypertension
DO - 10.1038/ajh.2010.233
DA - 2011-03-01
UR - https://www.deepdyve.com/lp/oxford-university-press/hemoglobin-a1c-body-mass-index-and-the-risk-of-hypertension-in-women-25PSSC806A
SP - 328
EP - 334
VL - 24
IS - 3
DP - DeepDyve
ER -