TY - JOUR
AU - Tsibouklis, John
AB - Copolymeric hydrogels constituting of vinylpyrrolidone and methacrylic or acrylic acid repeat units have been prepared and investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. The materials were synthesized by radical‐induced polymerization in the presence of N,N′‐methylenebisacrylamide crosslinker, and the influences of network composition and drug solubility upon the swelling properties, adhesion behavior, and drug release characteristics were studied. In vitro release experiments showed that some of these materials could be useful vehicles for the delivery of drugs such as pilocarpine or chloramphenicol, while in vivo studies, using the rabbit model, confirmed their high potential for the controlled ocular delivery of pilocarpine hydrochloride. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005
TI - Vinylpyrrolidone‐ co ‐(meth)acrylic acid inserts for ocular drug delivery: Synthesis and evaluation
JO - Journal of Biomedical Materials Research Part A
DO - 10.1002/jbm.a.30329
DA - 2005-09-15
UR - https://www.deepdyve.com/lp/wiley/vinylpyrrolidone-co-meth-acrylic-acid-inserts-for-ocular-drug-delivery-1kqmVNVZfu
SP - 598
EP - 606
VL - 74A
IS - 4
DP - DeepDyve
ER -