TY - JOUR
AU - Crawford, Dorothy H.
AB - A mouse monoclonal antibody (MAb) against Epstein-Barr virus (EBV) envelope glycoprotein 350, 72A1, inhibited EBV infection of B lymphocytes in vitro. When severe combined immunodeficient mice were injected with EBV-seronegative donors’ peripheral-blood mononuclear cells and challenged with EBV, 72A1 MAb prevented development of EBV-positive tumors: none of the test mice (0/12) developed EBV-positive tumors. In contrast, 67% (8/12) of control mice developed EBV-positive tumors (P=.001). Purified 72A1 MAb was infused into 1 healthy adult and 4 EBV-seronegative children after liver transplant. No adverse reactions were seen in the adult or in 3 of the transplant recipients. The remaining patient developed a hypersensitivity reaction, thus underlining the need to humanize the MAb
TI - A Mouse Monoclonal Antibody against Epstein-Barr Virus Envelope Glycoprotein 350 Prevents Infection Both In Vitro and In Vivo
JF - Journal of Infectious Diseases
DO - 10.1086/505912
DA - 2006-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/a-mouse-monoclonal-antibody-against-epstein-barr-virus-envelope-1fbBi2Vtj3
SP - 584
EP - 587
VL - 194
IS - 5
DP - DeepDyve
ER -