TY - JOUR AU1 - Venkatraman, Subbu S. AB - ORIGINAL ARTICLE A Novel Biodegradable Septal Defect Occluder The “Chinese Lantern” Design, Proof of Concept Wei Wu, PhD,* James Yip, MD,† Yong-Dan Tang, PhD,* Vincent Khoo, BEng,* Jen Fong Kong, BEng,* Duc Duong-Hong, PhD,* Freddy Boey, PhD,* and Subbu S. Venkatraman, PhD* Key Words: Patent foramen ovale, Atrial septal defect, Transcath- Objective: Atrial septal defect (ASD) is a general term used to eter device closure, Biodegradable polymer. describe an opening in the atrial septum that divides the two atria; (Innovations 2011;6:221–230) unless the hole is occluded, it can give rise to serious complications. Given the need for percutaneous deployment for ASD or patent fora- men ovale (PFO) occluders, all currently available devices are made trial septal defect (ASD) and patent foramen ovale (PFO) of metals (specifically nitinol) and synthetic fabric. However, their Aare two major types of congenital septal abnormalities. permanent presence in the human body is not desirable due to the risks ASD is a common congenital heart disease occurring in 5 to of long-term allergy, toxicity, and complications such as thrombus 7 per 10,000 live births, accounting for 25% to 30% of formation, device arm fracture, and nickel allergy. Once the hole is congenital heart defects that TI - A Novel Biodegradable Septal Defect Occluder The “Chinese Lantern” Design, Proof of Concept JF - Innovations:Technology and Techniques in Cardiothoracic and Vascular Surgery DO - 10.1097/IMI.0b013e31822a2c42 DA - 2011-07-01 UR - https://www.deepdyve.com/lp/wolters-kluwer-health/a-novel-biodegradable-septal-defect-occluder-the-ldquo-chinese-lantern-1faytsR0uX SP - 221 EP - 230 VL - 6 IS - 4 DP - DeepDyve ER -