TY - JOUR
AU - Trenholme, Gordon M.
AB - During a recent clinical trial of ciprofloxacin in the therapy of acute diarrhea, two subjects infected with Campylobacter jejuni who received ciprofloxacin failed microbiologically and one also failed clinically. Although both pretreatment isolates were susceptible to ciprofloxacin, the posttreatment isolates were resistant to ciprofloxacin (MIC = 32 µg/ml) and to other quinolones. The posttreatment isolates remained susceptible to nonquinolone antimicrobials. DNA gyrase holoenzyme was isolated from one of the resistant posttreatment isolates and was 8- to 16-fold less sensitive to inhibition by ciprofloxacin than was the gyrase from the paired pretreatment susceptible isolate. Ciprofloxacin accumulation was diminished in the two resistant posttreatment isolates. These results show that mutation in C. jejuni can occur in vivo and is associated with clinically significant resistance to the newer quinolones.
TI - High-Level Quinolone Resistance in Clinical Isolates of Campylobacter jejuni
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/165.4.667
DA - 1992-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/high-level-quinolone-resistance-in-clinical-isolates-of-campylobacter-1d01z0TDWl
SP - 667
EP - 670
VL - 165
IS - 4
DP - DeepDyve
ER -