TY - JOUR AU1 - Haberal, Mehmet AB - ORIGINAL ARTICLE An In Vivo Comparison of Commonly Used Topical Antimicrobials on Skin Graft Healing After Full-Thickness Burn Injury Ozan L. Abbas,* Huseyin Borman, MD,† Taner Bahar, MD, PhD,† Nilgün M. Ertaş, PhD,† Mehmet Haberal, MD‡ Topical antimicrobials are frequently used for local control of infections in burn patients. It has been postulated that these agents retard wound healing. There are limited data about the effects of topical antimicrobial agents on skin graft healing. In this study, we aimed to evaluate the effects of nitrofurazone, 1% silver sulfadiazine, and povidone-iodine on skin graft healing. Forty male rats were used in this study. A meshed skin graft, placed on an excised burn wound, was used as a model to compare topical agents with a control group. Skin graft survival rates, closure of meshed graft interstices (based on physical parameters, namely epithelialization and wound contraction), and histological changes were analyzed. Graft take was more than 85% in all groups. There was no difference between the mean values of the percent graft survival for each group (P > .05). Epithelialization occurred significantly earlier in animals in the nitrofurazone group (P < .05). There was no significant difference between groups in wound contraction TI - An In Vivo Comparison of Commonly Used Topical Antimicrobials on Skin Graft Healing After Full-Thickness Burn Injury JF - Journal of Burn Care & Research DO - 10.1097/BCR.0000000000000072 DA - 2015-03-01 UR - https://www.deepdyve.com/lp/wolters-kluwer-health/an-in-vivo-comparison-of-commonly-used-topical-antimicrobials-on-skin-1bcUWBe1Q7 SP - e47–e54-e47&ndash EP - ndash;e54-e47–e54 VL - 36 IS - 2 DP - DeepDyve ER -