TY - JOUR
AU1 - Qin, Qin
AU2 - Shi, Yunjie
AU3 - Zhao, Qingqing
AU4 - Luo, Dan
AU5 - Chen, Yuan
AU6 - Wu, Jing
AU7 - Zhao, Min
AB - Graefes Arch Clin Exp Ophthalmol (2015) 253:1765–1776 DOI 10.1007/s00417-015-3067-2 CORNEA Effects of CD25siRNA gene transfer on high-risk rat corneal graft rejection 1 1 1 1 Qin Qin & Yunjie Shi & Qingqing Zhao & Dan Luo & 1 1 1 Yuan Chen & Jing Wu & Min Zhao Received: 3 January 2015 /Revised: 13 April 2015 /Accepted: 15 May 2015 /Published online: 31 May 2015 Springer-Verlag Berlin Heidelberg 2015 Abstract and less graft oedema. Lower CD25 and higher IL-10 expres- Background Corneal graft rejection is the major cause of cor- sion were detected in the CD25siRNA treatment groups dur- neal failures. Previous studies have shown that the CD25 ing the study period, and a higher FOXP3 level was found in monoclonal antibody can inhibit corneal graft rejection during the CD25siRNA group than in the CD25siRNA-twice group the acute phase of rejection in rat models. In the current study, on days 14 and 21 post-operation. we evaluated the safety and efficacy of the topical Conclusions The Entranster™ vector is an effective vector for Entranster™ vector in rat corneal applications and further in- corneal gene therapy. CD25 siRNA gene transfer inhibits cor- vestigated the effects of CD25siRNA gene transfer on high- 
TI - Effects of CD25siRNA gene transfer on high-risk rat corneal graft rejection
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
DO - 10.1007/s00417-015-3067-2
DA - 2015-05-31
UR - https://www.deepdyve.com/lp/springer-journals/effects-of-cd25sirna-gene-transfer-on-high-risk-rat-corneal-graft-1XDtwLt91X
SP - 1765
EP - 1776
VL - 253
IS - 10
DP - DeepDyve
ER -