TY - JOUR
AU - Stein, Hubert J.
AB - Abstract In the mammalian cell, molecular oxygen is essential for energy production through oxidative phosphorylation. Cell death will rapidly ensue in the absence of oxygen. Under normal circumstances, most of the molecular oxygen undergoes tetravalent reduction to water by the following intracellular cytochrome oxidase system: However, under certain circumstances, univalent reduction can occur with transfer of only one electron (e− ), resulting in the release of highly reactive free radical intermediates. This presents an immediate and severe threat to the integrity of the cell. With this highly lethal potential for self-destruction, it is clear that some form of natural protection is required in mammals with oxidative metabolism. This protection exists in the form of endogenous antioxidants or enzymes, such as glutathione peroxidase, superoxide dismutase, and catalase, which are found in varying concentrations in most mammalian cells, and which, under normal physiologic conditions, protect the cell from attack by free radicals. Under certain References 1. Cerutti PA. Prooxidant states and tumor promotion . Science . 1985;227:375-381.Crossref 2. Harman D. Aging: a theory based on free radical and radiation chemistry . J Gerontol . 1956;11:298-300.Crossref 3. Phelps DL, Rosenbaum AL. Vitamin E in kitten oxygen-induced retinopathy, II: blockage of vitreal neovascularization . Arch Ophthalmol . 1979;97:1522-1526.Crossref 4. Marx JL. Oxygen free radicals linked to many diseases . Science . 1987;235:529-531.Crossref 5. Hunninghake G, Gadek J, Crystal R. Mechanism by which cigarette smoke attracts polymorphonuclear leukocytes to lung . Chest . 1980;77:273.Crossref 6. Del Maestro RF, Thaw HH, Bjorj J, Planker M, Arfors KE. Free radicals as mediators of tissue injury . Acta Physiol Scand Suppl . 1980;492:43-57. 7. Halliwell B, Gutteridge JMC. Oxygen toxicity, oxygen radicals, transition metals and disease . Biochem J . 1984;219:1-14. 8. McCord J M, Fridovich I. The reduction of cytochrome c by milk oxidase . J Biol Chem . 1968;243:5753-5760. 9. Blake DR, Lunec J, Winyard P, Brailsford S. Iron, free radicals and chronic inflammation . In: Moll JMH, Sturrock RD, eds. Recent Advances in Rheumatology 4 . New York, NY: Churchill Livingstone Inc; 1986:21-36. 10. Weiss SJ. Oxygen, ischaemia and inflammation . Acta Physiol Scand Suppl . 1986;548:9-37. 11. Babior BM. Oxygen-dependent killing by phagocytes . N Engl J Med . 1978;298:659-668.Crossref 12. Barber AA, Bernheim F. Lipid peroxidation: its measurement, occurrence and significance in animal tissues . Adv Gerontol Res . 1967;2:355-403. 13. Weiss SJ, Peppin G, Ortiz X, Ragsdale C, Test ST. Oxidative autoactivation of latent collagenase by human neutrophils . Science . 1985;227:747-749.Crossref 14. Svensson LG, von Ritter C, Oosthuizen MMJ, et al. Prevention of gastric mucosal lesions following aortic cross-clamping . Br J Surg . 1987;74:282-285.Crossref 15. Kaetzel CS, Mather IH, Bruder G, Madara PJ. Characterization of a monoclonal antibody to bovine xanthine oxidase . Biochem J . 1984;219:917-925. 16. Tsan MF, White JE, Rosano CL. Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester . J Appl Physiol . 1989;66:1029. 17. Hutchinson F. The distance that a radical formed by ionizing radiation can diffuse in a yeast cell . Radiat Res . 1957;7:473-483.Crossref 18. Paty PB, Graeff RW, Mathes SJ, Hunt TK. Superoxide production by wound neutrophils . Arch Surg . 1990;125:65-69.Crossref 19. Smith SM, Holm-Rutli L, Perry MA, et al. Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat . Gastroenterology . 1987;93:466-471. 20. Hernandez LA, Grisham MB, Twohig B, Arfors KE, Harlan JM, Granger DN. Role of neutrophils in ischemia/reperfusion-induced microvascular injury . Am J Physiol . 1987;253:699-703. 21. von Ritter C, Hinder RA, Oosthuizen MMJ, Svensson L, Hunter SJS, Lambrecht H. Gastric mucosal lesions induced by hemorrhagic shock in baboons: the role of oxygen derived free radicals . Dig Dis Sci . 1988;33:857-864.Crossref 22. Svensson LB, von Ritter C, Groenefeldt HT, et al. Cross-clamping of the thoracic aorta: influence of aortic shunts, laminectomy, papaverine, calcium channel blocker, allopurinol and superoxide dismutase on spinal cord blood flow and paraplegia in baboons . Ann Surg . 1986;204:38-47.Crossref 23. Southorn PA, Powis G. Free radicals in medicine, II: involvement in human disease . Mayo Clin Proc . 1988;63:390-408.Crossref 24. Stein HJ, Fayman MS, Oosthuizen MMJ, Hinder RA. Verapamil improves survival of rat hyperemic island skin flaps . Surgery . 1989;106:617-623. 25. Williams JG, Hallet MB. Effect of sulphasalazine and its active metabolite, 5-amino-salicylic acid, on toxic oxygen metabolite production by neutrophils . Gut . 1989;30:1581-1587.Crossref 26. Jaeschke H, Smith CV, Mitchell JR. Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver . J Clin Invest . 1988;81:1240.Crossref 27. Belzer FO, Southard JH. Principles of solid organ preservation by cold storage . Transplantation . 1988;45:673.Crossref 28. Metzger J, Dore SP, Lauterburg BH. Oxidant stress during reperfusion of ischemic liver: no evidence for a role of xanthine-oxidase . Hepatology . 1988;8:580.Crossref 29. Stein HJ, Esplugues J, Whittle BJR, Bauerfeind P, Hinder RA, Blum AL. Direct cytotoxic effect of oxygen radicals on the gastric mucosa . Surgery . 1989;106:318-324. 30. Williams JG. Phagocytes, toxic oxygen metabolites and inflammatory bowel disease: implications for treatment . Ann R Coll Surg Engl . 1990;72:253-262. 31. Guice KS, Oldham KT, Johnson KJ. Failure of antioxidant therapy (polyethylene glycol-conjugated catalase) in acute pancreatitis . Am J Surg . 1989;157:145-149.Crossref 32. Granger DN, Rutili G, McCord JM. Superoxide radicals in feline intestinal ischemia . Gastroenterology . 1981;81:22-29. 33. Goebel KM, Stock U. Effect of intra-articular orgotein versus a corticosteroid on rheumatoid arthritis of the knees . Am J Med . 1983;74:124-128.Crossref 34. Goebel KM, Stock U, Neurath F. Intrasynovial orgotein therapy in rheumatoid arthritis . Lancet . 1981;1:1015-1017.Crossref 35. Stern LZ, Ringel SP, Ziter FA, et al. Drug trial of superoxide dismutase in Duchenne's muscular dystrophy . Arch Neurol . 1982;39:342-346.Crossref 36. Greenwald RA. Therapeutic benefits of oxygen radical scavenger treatments remain unproven . J Free Radic Biol Med . 1985;1:173-177.Crossref
TI - Oxygen-Derived Free Radicals
JO - Archives of Surgery
DO - 10.1001/archsurg.1991.01410250112019
DA - 1991-01-01
UR - https://www.deepdyve.com/lp/american-medical-association/oxygen-derived-free-radicals-1PDY9ruIoB
SP - 104
EP - 105
VL - 126
IS - 1
DP - DeepDyve
ER -