TY - JOUR AU - Pockley, A. Graham AB - AJH 2006; 19:232–233 Reviewer Critique Cross-Sectional Correlates of Serum Heat Shock Protein 70 in the Community A. Graham Pockley he article by Dhingra et al in this issue of the prevalent in subjects with established hypertension with Journal reports data from a cross-sectional study in high levels of circulating Hsp70 at enrollment suggests T which the authors used a commercially available that elevated levels of Hsp70 protect against, rather than enzyme immunoassay kit to measure levels of circulating exacerbate, cardiovascular disease. The finding that cir- heat shock protein 70 (Hsp70) in samples from 456 par- culating Hsp70 levels in individuals evaluated for coro- ticipants in the Framingham Offspring Study. The authors nary artery disease were higher in patients without have related circulating levels of Hsp70 to a number of evidence of coronary artery disease in a cross-sectional parameters that are associated with the presence of car- study supports this concept. diovascular disease and disproved their hypothesis that The authors did not determine levels of circulating serum levels of Hsp70 are related to the presence and antibodies to stress proteins such as Hsp60 and Hsp70 in levels of established risk factors for cardiovascular disease this study, despite the fact that TI - Cross-Sectional Correlates of Serum Heat Shock Protein 70 in the Community JF - American Journal of Hypertension DO - 10.1016/j.amjhyper.2005.11.002 DA - 2006-02-01 UR - https://www.deepdyve.com/lp/oxford-university-press/cross-sectional-correlates-of-serum-heat-shock-protein-70-in-the-1MsszPQKC3 SP - 232 EP - 233 VL - 19 IS - 2 DP - DeepDyve ER -