TY - JOUR
AU - Kellogg, Mark D.
AB -  Clin Chem Lab Med 2017; 55(7): e154­e157 Letter to the Editor Roy W.A. Peake*, Terence Law, Christopher L. Esposito and Mark D. Kellogg DOI 10.1515/cclm-2016-0727 Received August 13, 2016; accepted September 27, 2016; previously published online October 18, 2016 Keywords: busulfan; LC-MS/MS; random-access. To the Editor, Advances in analytical performance and high-throughput capability have vastly improved the scope of clinical LC-MS/MS. One application where LC-MS/MS continues to lag behind is random-access functionality. At present, LC-MS/MS is largely limited to batch analyses, restricting the technology to measurement of analytes for which expedited turnaround is not a requirement. Over the past decade, the use of online multi-channel sample preparation systems has enabled greater speed and flexibility in assay provision [1]. Automation of sample preparation and the emergence of instruments and reagent kits designed for in-vitro diagnostics have helped integrate LC-MS/MS into the laboratory workflow [2, 3]. More recently, the use of isotopic internal calibration have suggested a reduced dependence on calibration curves [4]. Despite these endeavors, it remains uncertain as to whether LC-MS/ MS truly offers the simplicity, reliability and flexibility to operate in a random-access fashion. We describe a working LC-MS/MS model incorporating routine batch methods for vitamin D 
TI - Towards a random-access LC-MS/MS model for busulfan analysis
JF - Clinical Chemistry and Laboratory Medicine (CCLM)
DO - 10.1515/cclm-2016-0727
DA - 2017-06-27
UR - https://www.deepdyve.com/lp/de-gruyter/towards-a-random-access-lc-ms-ms-model-for-busulfan-analysis-1Mc3r9FoAY
SP - e154
VL - 55
IS - 7
DP - DeepDyve
ER -