TY - JOUR
AU1 - Cantoni, L.
AU2 - Wenger, A.
AU3 - Glauser, M. P.
AU4 - Bille, J.
AB - THE JOURNAL OF INFECTIOUS DISEASES. VOL. 159, NO.5. MAY 1989 © 1989 by The University of Chicago. All rights reserved. 0022-1899/89/5905-0026$01.00 Comparative Efficacy of Amoxicillin-Clavulanate, Cloxacillin, and Vancomycin Against Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Endocarditis in Rats Since the introduction of methicillin into clinical medicine rope, the USA, Australia) were studied. All of the strains in 1959 the prevalence of Staphylococcus aureus strains were ll-lactamase producers and thus were resistant to pen­ resistant to this antibiotic has reached epidemic propor­ icillin. When tested by a disk diffusion method as recom­ tions in certain geographic areas. The therapeutic options mended by the National Committee for Clinical Labora­ for treating such strains are largely limited to vancomy­ tory Standards (NCCLS) [6], 71 strains were found to be cin. The ll-lactamase-resistant penicillins and cephalospo­ methicillin-sensitive (Kirby Bauer inhibition diameter ~13 rins have been controversial for the treatment of infections mm using a l-ug oxacillin disk in Mueller Hinton agar [MH; Difco Laboratories, Detroit] without NaCl). Ninety­ caused by these organisms [1]. Beta-lactamase inhibitors (e.g., clavulanic acid and sul­ six strains were methicillin-resistant (Kirby Bauer inhibi­ bactam) have a weak intrinsic antibacterial activity but act tion diameter "10 mm under the same testing 
TI - Comparative Efficacy of Amoxicillin-Clavulanate, Cloxacillin, and Vancomycin Against Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Endocarditis in Rats
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/159.5.989
DA - 1989-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/comparative-efficacy-of-amoxicillin-clavulanate-cloxacillin-and-1IPPMepXqm
SP - 989
EP - 993
VL - 159
IS - 5
DP - DeepDyve
ER -