TY - JOUR
AU - Hill, Heather
AB - Influenza A(H5N1) vaccination strategies that improve the speed of the immunological response and cross-clade protection are desired. We compared the immunogenicity of a single 15-g or 90-g dose of A/H5N1/Indonesia/05/05 (clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (clade 1) vaccine. High-dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low-dose priming with a mismatched pandemic influenza A(H5N1) vaccine would improve the rapidity, magnitude, and cross-reactivity of the immunological response following a single high-dose, unadjuvanted, pandemic vaccine.
TI - Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/jiv087
DA - 2015-08-15
UR - https://www.deepdyve.com/lp/oxford-university-press/safety-and-immunogenicity-of-a-single-low-dose-or-high-dose-of-clade-2-1GvWfSjRY2
SP - 525
EP - 530
VL - 212
IS - 4
DP - DeepDyve
ER -