TY - JOUR
AU - Taniguchi, Nobuyuki
AB - Objective: The aim of this study was to investigate the relationship between metabolic risk factors and oxidative stress using urinary 8-hydroxydeoxyguanosine (8-OHdG), a recently utilized biological marker, in asymptomatic subjects. Methods: Ninety subjects (males/females = 30/60; mean age = 52 years), who were nonsmoking, nondiabetic and not on any medicine, were enrolled in the study. The body mass index, blood pressure, total cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and glucose as well as urinary 8-OHdG and creatinine were measured. Results: The median level of 8-OHdG was 9.3 ng/mg creatinine (interquartile range: 5.8–23.2). TG (Pearson’s correlation: r = 0.262, p = 0.013) and HDL-C (r = –0.259, p = 0.014) showed a significant correlation with 8-OHdG. A multiple linear regression analysis adjusted for all the variables revealed that only TG had an independently significant and positive correlation with 8-OHdG (β = 0.231, p = 0.046). Conclusion: The data in this population suggest that, among metabolic risk factors, hypertriglyceridemia may be weakly but significantly associated with hyperoxidative stress as assessed by 8-OHdG.
TI - The Relationship between Urinary 8-Hydroxydeoxyguanosine and Metabolic Risk Factors in Asymptomatic Subjects
JF - Medical Principles and Practice
DO - 10.1159/000319774
DA - 2011-01-01
UR - https://www.deepdyve.com/lp/karger/the-relationship-between-urinary-8-hydroxydeoxyguanosine-and-metabolic-1Bbv4HDNc0
SP - 187
EP - 190
VL - 20
IS - 2
DP - DeepDyve
ER -