TY - JOUR
AU1 - Zwahlen, André
AU2 - Nydegger, Urs E.
AU3 - Vaudaux, Pierre
AU4 - Lambert, Paul-Henri
AU5 - Waldvogel, Francis A.
AB - A local defense mechanism in bacterial meningitis was evaluated in humans by measuring complement-mediated opsonic activity (CMOA) in normal and infected cerebrospinalfluid (CSF) with a complement-dependent phagocytic bactericidal assay. CMOA was absent in normal untreated CSF and remained undetectable in 20 samplesof CSF from patients with viral meningitis and five samples from patients with acute meningococcemia. In contrast, 15 of 27 samples of CSF from patients with acutebacterial meningitis had a measurable CMOA, which was correlated with protein concentrations (P < 0.01) and C4 hemolytic activity (P < 0.001) in the CSF. A favorable outcomeof bacterial meningitis was associated with the presence of CMOA in CSF (P < 0.005). Recovery was also correlated with higher levels of C4 (P < 0.01) and C3 (P< 0.05) in CSF and with lower concentrations of microorganisms in the sample of CSF collected at the time of admission (P < 0.01). Thus, CMOA, although absent in normalCSF, can appear in CSF during acute bacterial meningitis, particularly in patients who recover completely.
TI - Complement-Mediated Opsonic Activity in Normal and Infected Human Cerebrospinal Fluid: Early Response During Bacterial Meningitis
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/145.2.635
DA - 1982-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/complement-mediated-opsonic-activity-in-normal-and-infected-human-0z0G1hVafl
SP - 635
EP - 646
VL - 145
IS - 5
DP - DeepDyve
ER -