TY - JOUR
AU1 - Vedros, Neylan A.
AU2 - Fishel, Charles W.
AB - THE PRESENCE OF C-REACTIVE PROTEIN IN FRACTIONATED NORMAL HUMAN SERA* NEYLAN A. VEDROSt AND CHARLES W. FISHEL From the Department of Microbiology, University of Colorado School of Medicine, Denver, Colorado A substance which reacts and pre­ the method of Kunkel and Slater (1952) cipitates with pneumococcal C poly­ was used for starch electrophoretic saccharide has been detected in the sera separation of the serum fractions. Puri­ of individuals with a variety of clinical fied potato starch (Mallinckrodt) was conditions (Hedlund, 1961). The pres­ mixed with an equal volume of veronal ence of this nonantibody serum factor, buffer (pH 8.6,0.1 ionic strength) and C-reactive protein (CRP), has been ac­ the paste poured into a tray to form a cepted as one of several nonspecific in­ block measuring 20 X 6 Xl cm. Two ml dicators of disease. Little is known con­ of serum were mixed with an equal vol­ cerning the origin of this substance ume of the buffer and starch. The mix­ which in acute infections appears dur­ ture was poured into a precut rec­ ing the febrile phase and subsequently tangular slit approximately 8 cm from disappears upon clinical recovery. The one end of the block. Filter paper 
TI - The Presence of C-Reactive Protein in Fractionated Normal Human Sera*
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/114.5.429
DA - 1964-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-presence-of-c-reactive-protein-in-fractionated-normal-human-sera-0mLKoLHJD0
SP - 429
EP - 434
VL - 114
IS - 5
DP - DeepDyve
ER -