TY - JOUR AU - Schlom, J. AB - Cancer Immunol Immunother (1996) 43: 127 – 134 Springer-Verlag 1996 SYMPOSIUM I N W RIT I NG James W. Hodge Received: 6 August 1996 / Accepted: 20 September 1996 Key wordsmAnti-idiotype ? Recombinant poxviruses ? glycophosphatidylinositol (CEA, NCA, CGM-6), and those Polynucleotide immunization ? Carcinoembryonic antigen ? that have both transmembrane and cytoplasmic domains Immunotherapy ? Cancer vaccines (BGP splice variants). There appear to be several biological functions of CEA and CEA family members in normal and neoplastic cells. CEA family members have also been implicated in the binding of selectins [31]. Several in vitro studies have Introduction shown that CEA, NCA, CGM-6, and BGP function as homotypic and heterotypic intercellular adhesion molecules Biology of carcinoembryonic antigen [31, 34, 36]. It has been proposed that the adhesion function of CEA may contribute to the development of tissue The carcinoembryonic antigen (CEA) gene family consists structure during embryogenesis and in normal adult colon of 29 separate genes, which are located within the long arm [2]. In this model, overexpression of CEA during carcino- of chromosome 19. In 1986, the isolation of cDNA or genes genesis would cause the development of a multilayered for CEA family members led to their TI - Carcinoembryonic antigen as a target for cancer vaccines JF - Cancer Immunology Immunotherapy DO - 10.1007/s002620050313 DA - 1996-12-01 UR - https://www.deepdyve.com/lp/springer-journals/carcinoembryonic-antigen-as-a-target-for-cancer-vaccines-0lZBJpHD0Z SP - 127 EP - 134 VL - 43 IS - 3 DP - DeepDyve ER -