TY - JOUR
AU - Lewis, D.H.
AB - Using a quantitative method, involving radioactive labelling of the erythrocytes, platelets and fibrinogen, the relative distribution of these elements was evaluated in the blood and various organs before and after trauma to the hindleg of the dog. It was found that the <sup>59</sup>Fe activity (= erythrocytes) increased in the blood concomitant with a haematocrit increase. This activity also increased to a small degree in the kidney but otherwise was unchanged in the other organs studied. <sup>51</sup>Cr was used as a platelet label. The <sup>51</sup>Cr activity decreased in blood and increased markedly in the lung and also in the kidney. It was unchanged in the traumatized muscle but decreased in the untraumatized muscle. Fibrinogen was labelled with <sup>125</sup>I. This activity decreased in the blood, increased in the traumatized muscle and decreased in the untraumatized muscle but was unchanged in the lung and kidney. Essentially the same pattern was found in dogs treated with a fibrinolytic inhibitor (AMCA). The results indicate that platelets are aggregated in the posttraumatic period and have a special tendency to accumulate in the lung and probably also in the kidney. Fibrin was not deposited in the lung and kidney even if fibrinolysis was blocked with an antifibrinolytic agent (AMCA).
TI - The Distribution of Platelets, Fibrin and Erythrocytes in Various Organs following Experimental Trauma
JO - European Surgical Research
DO - 10.1159/000127568
DA - 1971-01-01
UR - https://www.deepdyve.com/lp/karger/the-distribution-of-platelets-fibrin-and-erythrocytes-in-various-0dNsY7GO7U
SP - 293
EP - 300
VL - 3
IS - 5
DP - DeepDyve
ER -