TY - JOUR
AU - Vanelle, Patrice
AB - Since its introduction in 1981, the chemistry of self-immolative systems has received increasing attention in different application areas, such as analytical chemistry, medicinal chemistry, and materials science. This strategy is based on a stimulation that triggers a cascade of disassembling reactions leading to the release of smaller molecules. The particular reactivity of the nitro group, due to its powerful electron-withdrawing nature, has been exploited in the field of self-immolative chemistry. In this context, the present review describes the major role of the nitro group in self-immolative processes depending on its position.
TI - Nitro-Containing Self-Immolative Systems for Biological Applications
JF - Pharmaceuticals
DO - 10.3390/ph15111404
DA - 2022-11-14
UR - https://www.deepdyve.com/lp/multidisciplinary-digital-publishing-institute/nitro-containing-self-immolative-systems-for-biological-applications-0dGS0T2scF
SP - 1404
VL - 15
IS - 11
DP - DeepDyve
ER -