TY - JOUR
AU1 - Adzima, Brian J.
AU2 - Bowman, Christopher N.
AB -  Introduction A new paradigm encompassing several distinct chemical reactions and, more importantly, a generalized approach to molecular design and synthesis has been rapidly adopted in the fields of chemical synthesis, biotechnology, materials science, drug discovery, surface science, and polymer synthesis and modification. Click chemistry focuses on highly efficient reactions that reach quantitative conversion under mild conditions and require only facile separations. Key to this approach is the desire to achieve molecules and materials with the desired properties, behavior, and characteristics rather than a target molecular structure. Click reactions are ideal candidates for broad implementation and development in chemical and biological engineering. In this Perspective, the authors discuss the tenents of click chemistry, its adoption across several fields, and three of the most widely implemented click reactions in these areas including the original Cu catalyzed alkyne‐azide cycloaddition reaction, the thiol‐X family of click reactions and the Diels–Alder reaction. The Click reaction paradigm and its history The extraction of value from any given chemical synthesis process is a forte of the chemical engineering field and involves a complex underpinning in fundamental transport processes, reactor design, reaction kinetics, separations, materials cost, and many other factors. That said, an often overlooked part 
TI - The emerging role of click reactions in chemical and biological engineering
JF - Aiche Journal
DO - 10.1002/aic.13909
DA - 2012-10-01
UR - https://www.deepdyve.com/lp/wiley/the-emerging-role-of-click-reactions-in-chemical-and-biological-0ZCp8CfW80
SP - 2952
EP - 2965
VL - 58
IS - 10
DP - DeepDyve
ER -