TY - JOUR
AU - Lyons, Norman
AB - A method is described for the determination of GFR and ERPF using a combined injection of 51Cr-EDTA and 125I-iodohippurate. Plasma samples obtained at 60 min and 150 min after administration were used to determine a flow rate F assuming a monoexponential clearance of the tracers. Empirical relationships were found between F and the true GFR and ERPF determined from multiple sampling and multi-exponential analysis of the clearance curves. The method was shown to be superior to previously published methods involving one or two samples. GRF was calculated with a standard deviation (SD) of only 3.3 ml/min when compared to the multiple sample technique (the reference method), whereas the best estimate from a single sample had a SD of 6.3 ml/min. An improvement in accuracy of ERPF estimation was achieved for values of flow of less than 200 ml/min when the SD was only 9.3 ml/min.
TI - Simplified estimation of glomerular filtration rate and effective renal plasma flow
JF - European Journal of Nuclear Medicine and Molecular Imaging
DO - 10.1007/BF00251347
DA - 2004-08-05
UR - https://www.deepdyve.com/lp/springer-journals/simplified-estimation-of-glomerular-filtration-rate-and-effective-0WaIxK4n9M
SP - 249
EP - 253
VL - 6
IS - 6
DP - DeepDyve
ER -