TY - JOUR AU1 - Thorén, Peter AU2 - Åsberg, Marie AU3 - Cronholm, Börje AU4 - Jörnestedt, Lennart AU5 - Träskman, Lil AB - Abstract • The effect of clomipramine hydrochloride in severe obsessive-compulsive disorder (OCD) was compared with that of nortriptyline hydrochloride and placebo in a five-week randomized, double-blind trial. Clomipramine, but not nortriptyline, was superior to placebo in interview-based ratings of severity of OCD. The effect was not clear-cut until after five weeks of treatment. When clomipramine was given openly to 22 patients after the end of the controlled trial, half of the patients responded to the drug. The response could not be predicted from severity or duration of illness, sex or age of the patient, or presence or absence of secondary depressive symptoms. The amelioration with clomipramine was not sustained if the drug was withdrawn. References 1. Goodwin DW, Guze SB, Robins E: Follow-up studies in obsessional neurosis . 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Br J Psychiatry 134:382-389, 1979.Crossref 27. Anderson NH: Scales and statistics: Parametric and nonparametric . Psychol Bull 58:305-316, 1961.Crossref 28. Boneau CA: A note on measurement scales and statistical tests . Am Psychol 16:160-261, 1961.Crossref 29. Ferguson GA: Statistical Analysis in Psychology and Education . New York, McGraw-Hill Book Co, 1971, p 271. TI - Clomipramine Treatment of Obsessive-Compulsive Disorder: I. A Controlled Clinical Trial JF - Archives of General Psychiatry DO - 10.1001/archpsyc.1980.01780240079009 DA - 1980-11-01 UR - https://www.deepdyve.com/lp/american-medical-association/clomipramine-treatment-of-obsessive-compulsive-disorder-i-a-controlled-0UXrLEbRMy SP - 1281 EP - 1285 VL - 37 IS - 11 DP - DeepDyve ER -