TY - JOUR
AU - Hariprashad, June
AB - To examine the experimental basis of treatment failures in T cell-deficient patients with intracellular infections, euthymic and athymic (nude) BALB/c mice were infected with Toxoplasma gondii and treated with sulfadiazine. All euthymic and nude mice survived during 2 weeks of sulfadiazine therapy. Once treatment was discontinued, 100% of euthymic mice survived while all nude mice died. Post-sulfadiazine treatment survival was enhanced in nude mice by reconstitution with either L3T4+ or Lyt-2+ cells and was reduced in euthymic mice by monoclonal antibody treatment directed at depleting either L3T4+ or Lyt-2+ cells or interleukin-2 (IL-2) or interferon-v (IFN-γ). These results suggest that although T cells and their products are not required for an initial response (survival) to treatment in acute experimental toxoplasmosis, survival off drug is strictly T cell-dependent. Optimal posttreatment survival appears to involve both L3T4+ helper and Lyt-2+ cytotoxic cells, probably acting in concert, as well as the endogenous secretion of at least two T cell-derived lymphokines, IL-2 and IFN-γ.
TI - Response to Treatment for an Intracellular Infection in a T Cell-Deficient Host: Toxoplasmosis in Nude Mice
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/167.5.1173
DA - 1993-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/response-to-treatment-for-an-intracellular-infection-in-a-t-cell-0SxuktCyBc
SP - 1173
EP - 1177
VL - 167
IS - 5
DP - DeepDyve
ER -