TY - JOUR
AU - Alexander,, Peter
AB - Summary The immunogenicity of syngeneic rat tumors that differ in their capacity to metastasize from an intramuscular graft in the leg was compared by measurement of the ability of the host to reject tumor after immunization with tumor cells sterilized by exposure to X-rays. This procedure provided strong protection for nonmetastasizing tumors, but was ineffective for some metastasizing tumors. Alternatively, immunity evoked by a growing tumor in the leg (concomitant immunity) was demonstrated by both metastasizing and nonmetastasizing tumors, though for the latter it was weaker than that produced by the inoculation of irradiated tumor cells. Concomitant immunity to a metastasizing tumor was expressed more strongly against cells injected intravenously or intradermally than intramuscularly. The failure of a metastasizing tumor to immunize after irradiation (whereas, as a growing tumor, it evokes immunologically specific host responses) is interpreted in terms of the spontaneous shedding of antigens. 2 Supported by grants from the Medical Research Council and Cancer Research Campaign. This content is only available as a PDF. Author notes 3 Division of Tumour Immunology, Chester Beatty Research Institute, Belmont, Sutton, Surrey, United Kingdom. 4 Present address: McGill University, Cancer Research Unit, McIntyre Medical Sciences Building, Montreal, Quebec, Canada H3G IY6. 5 Present address: Goteborg Universitet, Kir. klin. I, Sahlgrenska Sjukhuset, S—413 45 Goteborg, Sweden.
TI - A Preliminary Investigation Into the Role of Immunity in Modifying the Blood-Borne Spread of Chemically Induced Rat Sarcomas
JF - JNCI: Journal of the National Cancer Institute
DO - 10.1093/jnci/53.6.1671
DA - 1974-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/a-preliminary-investigation-into-the-role-of-immunity-in-modifying-the-0P0aOjvVCk
SP - 1671
EP - 1676
VL - 53
IS - 6
DP - DeepDyve
ER -