TY - JOUR
AU1 - Disabato, Brianne
AU2 - Sheline, Yvette
AB - Late life depression (LLD) is an important area of research given the growing elderly population. The purpose of this review is to examine the available evidence for the biological basis of LLD. Structural neuroimaging shows specific gray matter structural changes in LLD as well as ischemic lesion burden via white matter hyperintensities. Similarly, specific neuropsychological deficits have been found in LLD. An inflammatory response is another possible underlying contributor to the pathophysiology of LLD. We review the available literature examining these multiple facets of LLD and how each may affect clinical outcome in the depressed elderly.
TI - Biological Basis of Late Life Depression
JF - Current Psychiatry Reports
DO - 10.1007/s11920-012-0279-6
DA - 2012-05-06
UR - https://www.deepdyve.com/lp/springer-journals/biological-basis-of-late-life-depression-0MvQiq4t1s
SP - 273
EP - 279
VL - 14
IS - 4
DP - DeepDyve
ER -